Biophysical Characterization of Bladder Cancer Cells with Different Metastatic Potential
Liu H, Tan Q, Geddie WR, Jewett MA, Phillips N, Ke D, Simmons CA, Sun Y. Cell Biochem Biophys. 2013 Jun 21. [Epub ahead of print]


Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, ON, M5S 3G8, Canada.


Specific membrane capacitance (SMC) and Young's modulus are two important parameters characterizing the biophysical properties of a cell. In this work, the SMC and Young's modulus of two cell lines, RT4 and T24, corresponding to well differentiated (low grade) and poorly differentiated (high grade) urothelial cell carcinoma (UCC), respectively, were quantified using microfluidic and AFM measurements. Quantitative differences in SMC and Young's modulus values of the high-grade and low-grade UCC cells are, for the first time, reported.