Reproductive aging in men
Basaria S. Endocrinol Metab Clin North Am. 2013 Jun;42(2):255-70. doi: 10.1016/j.ecl.2013.02.012. Epub 2013 Apr 6.


Section of Men's Health, Aging and Metabolism, Brigham and Women's Hospital, Harvard Medical School, 221 Longwood Avenue, 5th Floor, Boston, MA 02115, USA. Electronic address:


Aging in men is associated with a decrease in serum testosterone levels due to attrition in testicular Leydig cells and slowing of the hypothalamic GnRH pulse generator. The practicing endocrinologist is frequently consulted for consideration of testosterone therapy in older men with late-onset hypogonadism (LOH), a condition that many clinicians fail to distinguish from organic hypogonadism. Recent data using syndromic definition show that only 2% of 40-80-year-old men have LOH. Co-morbidities and obesity strongly contribute to LOH, suggesting that testosterone is a biomarker of health. Hence, prevention and treatment of these co-morbidities might attenuate age-related decline in androgen levels.