Testosterone Concentrations In Young Pubertal And Post-Pubertal Obese Males
Mogri M, Dhindsa S, Quattrin T, Ghanim H, Dandona P. Clin Endocrinol (Oxf). 2012 Sep 13. doi: 10.1111/cen.12018. [Epub ahead of print]

Source

Division of Pediatric Endocrinology, Department of Pediatrics, State University of New York at Buffalo, Buffalo, NY, 14209.

Abstract

OBJECTIVE:

Obesity in adult males is associated with hypogonadotropic hypogonadism. We evaluated the effect of obesity on plasma testosterone concentrations in pubertal and post pubertal young males.

DESIGN AND METHODS:

Morning fasting blood samples were obtained from 25 obese (BMI>95(th) percentile) and 25 lean(BMI<85(th) percentile) males between the ages 14-20 years with Tanner staging >4. Total and free testosterone and estradiol concentrations were measured by liquid chromatography tandem mass spectrometry and equilibrium dialysis. Free testosterone was also calculated using SHBG and albumin. C-reactive protein (CRP), insulin and glucose concentrations were measured and homeostasis model of insulin resistance (HOMA-IR) was calculated.

RESULTS:

After controlling for age and Tanner staging, obese males had a significantly lower total testosterone(10.5 vs 21.44nmol/l), free testosterone(0.22 vs 0.39nmol/l) and calculated free testosterone(0.26 vs 0.44nmol/l) concentrations as compared to lean males(p<0.001 for all). Obese males had higher CRP concentrations (2.8 vs 0.8mg/l; p<0.001), and HOMA-IR (3.8 vs 1.1; p<0.001) than lean males. Free testosterone concentrations were positively related to age and negatively to BMI, HOMA-IR and CRP concentrations. Total and free estradiol concentrations were significantly lower in males with subnormal testosterone in concentrations.

CONCLUSION:

Testosterone concentrations of young obese pubertal and post pubertal males are 40-50% lower than those with normal BMI. Obesity in young males is associated with low testosterone concentrations which are not secondary to an increase in estradiol concentrations. Our results need to be confirmed in a larger number of subjects.