Pubertal Induction in Adult Males with Isolated Hypogonadotropic hypogonadism using Long-Acting Intramuscular Testosterone Undecanoate 1g depot (Nebido(®) )
Santhakumar A, Miller M, Quinton R. Clin Endocrinol (Oxf). 2013 Feb 5. doi: 10.1111/cen.12160. [Epub ahead of print]


Endocrine Unit, Royal Victoria Infirmary, Newcastle-upon-Tyne Hospitals Foundation NHS Trust.


Pubertal delay in males typically results from inadequate pulsatile secretion of hypothalamic gonadotropin-releasing hormone (GnRH), resulting in a biochemical profile of hypogonadotropic hypogonadism (low serum testosterone with low or inappropriately normal LH and FSH). In younger teenagers, this is most commonly due to constitutional delay (CDP), but the presence of organic gonadotropin deficiency (eg. idiopathic hypogonadotropic hypogonadism -IHH) is supported by a history of cryptorchidism, the presence of non-reproductive defects (anosmia, deafness, clefting, etc), and becomes exponentially more likely with increasing age at presentation. All forms of testosterone (exogenously-administered, or endogenously-generated) are able to induce the development of normal secondary sexual characteristics in apubertal young males, including short-acting IM injections of esterified testosterone (eg. Sustanon(®) ); oral testosterone undecanoate (oTU); hCG ±FSH sc injections, and pulsatile sc GnRH (1) . © 2013 Blackwell Publishing Ltd.