Hypogonadotropic hypogonadism associated with hereditary hemorrhagic telengiectasia
Valentina S, Daniele de S, Patrizia S, Patrizia L, Mariano LG, Vincenzo T, Carlo S. Case Rep Endocrinol. 2013;2013:465376. doi: 10.1155/2013/465376. Epub 2013 Apr 4.


Neurology Unit, "S. Maria del Pozzo" Hospital, Somma Vesuviana, 80049 Naples, Italy.


A 65-year-old man was referred to our clinic for the rehabilitation of right hemiparesis caused by ischaemic stroke. Hypertension, postphlebitic syndrome of lower limbs, frequent nose bleeding, and anemia were present in his history; in his adolescence, he was treated for idiopathic hypogonadotropic hypogonadism. Further investigations have revealed also microsomia, suggesting a clinical diagnosis of Kallmann syndrome, that is, an association, possible in males and females, of hypogonadotropic hypogonadism with olfactory deficits. A definite diagnosis of hereditary hemorrhagic telangiectasia was made based on clinical criteria and confirmed by genetic analysis.