Testosterone therapy improves psychological distress and health-related quality of life in Chinese men with symptomatic late-onset hypogonadism patients
Xiaowei Z, Zhenhua L, Yeqing Y, Wenjun B, Xiaofeng W, Huan S, Yongping Z. Aging Male. 2013 Jan 10. [Epub ahead of print]


Urology Department , and.


Abstract Background: Late onset hypogonadism negatively impacts on men's psychological well-being. More studies are needed in examining the interrelationship among symptoms of testosterone deficiency, psychological well-being and quality of life. Methods: Eligible subjects were randomized into active treatment and control groups, and were asked to complete the following questionnaires at baseline and Month 6: Aging Males' Symptoms (AMS) rating scale, Hospital Anxiety and Depression Scale (HADS), Perceived Stress Scale (PSS) and The Short Form Health Survey-12 (SF-12). In this study, men were treated and monitored for 6 months with oral testosterone undecanoate (TU) capsules or vitamin E/C capsules in a single-blinded fashion. All in the active treatment group were orally administered a total of 120-160 mg TU on a daily basis. Total and free T levels between baseline and Month 6 were compared. Results: One hundred and sixty eligible subjects were recruited and followed up. In the active treatment group, total serum testosterone concentrations before and after intervention were 230 ± 21 and 395 ± 34 ng/dL. The mean HADS anxiety subscale scores for the subjects at baseline and at Month 6 were 3.47 ± 0.4 and 1.72 ± 0.2, respectively (t = 1.526, p < 0.05). Additionally, the mean HADS depression subscale scores were 4.91 ± 0.6 and 2.39 ± 0.3, respectively (t = 3.466, p < 0.05). The mean scores on the PSS for the subjects at baseline and at Month 6 were 12.88 ± 2.1 and 9.83 ± 1.7, respectively (t = 4.009, p < 0.05). Significantly improved SF-12 could be observed (t = 1.433 and 1.118, respectively; both p < 0.05). No significant changes were observed in the control group at Month 6. Conclusion: Androgen replacement not only improves androgen deficiency-associated symptoms, but is also improves comprehensive improvement in psychological issues.