Impact of overactive bladder treatment on the quality of life of patients over 60 with associated pathologies
Espuña-Pons M, Castro-Díaz D, Díaz-Cuervo H, Pérez M. Arch Esp Urol. 2013 Apr;66(3):287-294.

[Article in English, Spanish]


Instituto Clínico de Ginecología y Obstetricia (ICGON). Hospital Clínico. Barcelona. Spain.



To study the impact of treatments prescribed in usual practice to control Overactive Bladder (OAB) on health-related quality of life (HRQoL) of patients with associated pathologies.


1.434 patients over 60 years with newly diagnosed OAB and at least one associated pathology (urinary or genital-skin infections, sleep disorders, depression, hypertension) were recruited in 300 urological/gynecological practices in Spain. During the first visit, socio-demographic and basic clinical information were registered and the therapeutic strategy for OAB was prescribed following usual clinical practice The patients filled out the HRQoL SF-12 questionnaire. On the second visit (4-6 months later) the HRQoL was re-evaluated. HRQoL was compared between sexes (Mann-Whitney) and between visits (Wilcoxon for related samples). Multiple regression models were performed in order to study the variables independently associated with HRQoL.


Valid data is given for 1,274 patients for visit 1 and 1,153 for visit 2. 71.51% of the sample were female. Mean age was 68.17 (6.19). A significant improvement in the HRQoL was found on the second visit. Factors independently associated with lower score in both summary index of SF-12: first visit, female gender and Charlson Index. Additional factors associated with reduction of the physical component score: age, all associated pathologies and treatment using vaginal pessaries. Additional factors associated with the mental component score: treatment for depression, sleep disorders, use of vesical reeducation and the modification of treatment using diuretics. CONCLUSIONS. The treatments prescribed in usual clinical practice to alleviate OAB are effective in notably improving the HRQoL of patients in general, both physically and mentally.