Cognitive adverse effects of anticholinergic medication for overactive bladder in PD/DLB
Sakakibara R. Rinsho Shinkeigaku. 2013;53(11):1389-92.

Neurology, Sakura Medical Center, Toho University.

Abstract

Overactive bladder (OAB) is a common autonomic disorder due mostly to lesions in the micturition-inhibiting area (D1 dopaminergic pathway in the basal ganglia) in Parkinson's disease (PD) and dementia with Lewy bodies (DLB). anticholinergic drugs are the mainstay in the treatment of OAB. However, since 1997, anticholinergic adverse events on the cognitive function have been recognized. Drugs with less lipophilic, less permeable through the blood-brain barrier are the choice in the treatment of OAB in elderly neurologic patients