Long-Term Experience With Sodium Chondroitin Sulfate in Patients With Painful Bladder Syndrome
Tornero JI, Olarte H, Escudero F, Gómez G. Actas Urol Esp. 2013 Jun 13. pii: S0210-4806(13)00012-0. doi: 10.1016/j.acuro.2013.01.008. [Epub ahead of print]

[Article in English, Spanish]


Servicio de Urología, Hospital Universitario Virgen de La Arrixaca, Murcia, España. Electronic address: ignaciotorne@hotmail.com.



To assess the response of patients diagnosed with painful bladder syndrome to treatment with instillations of sodium chondroitin sulfate.


We present a series of cases of patients with painful bladder syndrome who followed a bladder instillation protocol with sodium chondroitin sulfate, according to our centre's regimen. The response to treatment was assessed with respect to pain, according to the Downie scale; urinary frequency, according to the voiding diary; and subjective improvement, according to the Patient Global Impression of Improvement (PGI-I) scale.


A total of 28 patients with a median age of 59 years (range 22-90) followed this protocol. From the medical histories, 19.4% had suffered an infection of the urinary tract, 3.8% had suffered urinary tuberculosis, 7.6% received pelvic radiation therapy and 26.9% had taken anticholinergic drugs for overactive bladder syndrome. We evaluated the response to treatment at 0, 3, 6 and 12 months and found that at the end of treatment 72.3% of the patients had improved bladder pain and 75% were significantly better.


Treatment with sodium chondroitin sulfate through endovesical instillation in painful bladder syndrome improves pain, voiding frequency and quality of life in the long term.