Deformity Stabilization and Improvement in Men with Untreated Peyronie's Disease
Berookhim BM, Choi J, Alex B, Mulhall JP. BJU Int. 2013 Jul 2. doi: 10.1111/bju.12346. [Epub ahead of print]

Source

Male Sexual and Reproductive Medicine Program, Urology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY.

Abstract

OBJECTIVE:

To define predictors of the deformity stabilization and improvement in men with untreated Peyronie's disease (PD)

SUBJECTS AND METHODS:

The study population consisted of patients with PD-associated uniplanar curvature, who opted for no treatment and were followed for at least 12 months. All patients had deformity assessment (DA) performed on initial presentation and at follow-up. Stabilization of PD was defined as no change between deformity assessments (±10°), while improvement/progression were defined as ≥10° change. Patients were subdivided into different groups based on time to presentation: less than or equal to six months (A), seven to 12 months (B), and 13 to 18 months (C). Multivariable analysis was performed to define predictors of stabilization and improvement.

RESULTS:

176 men met the inclusion criteria. Mean age was 54 years, with mean PD duration of 9±12m and mean curvature of 42±27 degrees. 67% of the entire population had no change in deformity over time, 12% improved (mean change 27±14°), and 21% worsened (mean change 22±11°). On multivariate analysis, predictors of stabilization included: time to presentation of greater than six months (OR= 2.4, p<0.01), per decade increase in age (OR= 1.5, p<0.05), and age (r=0.32, p<0.05). Predictors of improvement included: time to presentation less than or equal to six months (OR= 4.1, p<0.001), and per decade decrease in age (OR= 2.1, p<0.01).

CONCLUSION:

In men with uniplanar curvature, PD stabilization and improvement rates change with time-to-presentation and patient age. These data may aid in counseling patients with PD.